Genetics of early Dictyostelium discoideum development.

EARLY DEVELOPMENT OF DICTYOSTELIUM DISCOIDEUM.................................................... 29 GENETIC ANALYSIS.................................................. 30 MUTANTS ALTERED IN AGGREGATION.................................................. 32 Numbers of Genes .................................................. 32 Selection Procedures.................................................. 33 Mutations That Affect Early Functions .................................................. 34 Mutations That Affect Later Events during Aggregation .................................................. 35 Mutations That Affect Many Events .................................................. 36 Rapid-development mutations.................................................. 36 Bypass mutations .................................................. 36 Mutants Defective in Known Functions .................................................. 36 Cyclic nucleotide phosphodiesterase .................................................. 36 csA(gp8O) .................................................. 37 ras.................................................. 38 cGMP phosphodiesterase .................................................. 38 Other developmentally regulated proteins .................................................. 38 GENES EXPRESSED DURING AGGREGATION .................................................. 38 CONTROL OF AGGREGATION .................................................. 40 Second Messenger Cascades .................................................. 40 Adaptive and Nonadaptive Gene Regulation .................................................. 40 ACKNOWLEDGMENTS .................................................. 43 LITERATURE CITED .................................................. 43